Publications and News

Updates on the Science and News of our Solutions

Over the last 10+ years, our work has been published in leading anti-fungal research journals and demonstrated in testing.

Recent NikZ reports

Mayattu K, Ghormade V. Controlled delivery of nikkomycin by PEG coated PLGA nanoparticles inhibits chitin synthase to prevent growth of Aspergillus flavus and Aspergillus fumigatus. Z Naturforsch C J Biosci. 2024 Jun 7;79(5-6):155-162.
https://doi.org/10.1515/znc-2023-0185
Limited availability

Wagner AS, Lumsdaine SW, Mangrum MM, Reynolds TB. Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels. mBio. 2023 Aug 31;14(4):e0007423.
https://doi.org/10.1128/mbio.00074-23
Epub 2023 Jun 28.

Adnan A, Borman AM, Tóth Z, Forgács L, Kovács R, Balázsi D, Balázs B, Udvarhelyi G, Kardos G, Majoros L. In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades. Pharmaceutics. 2023 Apr 29;15(5):1365.
htttps://doi.org/10.3390/pharmaceutics15051365

Sass G, Larwood DJ, Martinez M, Stevens DA. Continuous dosing of nikkomycin Z against systemic candidiasis, in vivo and in vitro correlates. Mycoses. 2023 May;66(5):378-386.
http://doi.org/10.1111/myc.13569
Epub 2023 Jan 30. PMID: 36680371
Limited availability

NikZ Eliminates Valley Fever

Larwood DJ. Nikkomycin Z-Ready to Meet the Promise? J Fungi (Basel). 2020 Oct 30;6(4):261.
https://doi.org/10.3390/jof6040261
PMID: 33143248; PMCID: PMC7712250.

Sass G, Larwood DJ, Martinez M, Chatterjee P, Xavier MO, Stevens DA. Nikkomycin Z against Disseminated Coccidioidomycosis in a Murine Model of Sustained-Release Dosing. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0028521.
https://doi.org/10.1128/AAC.00285-21
Epub 2021 Jul 12. PMID: 34252303; PMCID: PMC8448119.

Sass G, Larwood DJ, Martinez M, Shrestha P, Stevens DA. Efficacy of nikkomycin Z in murine CNS coccidioidomycosis: modeling sustained-release dosing. J Antimicrob Chemother. 2021 Sep 15;76(10):2629-2635.
http://doi.org/10.1093/jac/dkab223
PMID: 34269392
Limited availability

NikZ – Human safety

Nix, D.E.; Hoover, S.E.; Thompson, C.M.; Hanan, N.J..; Galgiani, J.N. Pharmacokinetics of and safety of nikkomycin Z after multiple rising doses in human subjects. Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Conference. 2011 (Sept 17)
Limited availability

Nix, D.E.; Swezey, R.R.; Hector, R.; Galgiani, J.N. Pharmacokinetics of nikkomycin Z after single rising oral doses. Antimicrob. Agents Chemother. 2009, 53, 2517–2521. [Google Scholar] [CrossRef] [Green Version]

NikZ against Candida Albicans – 100% Survival

Sass G, Larwood DJ, Stevens DA. Synergy in vitro of Nikkomycin Z with Azole Against the Invasive Form of Candida albicans. Mycopathologia. 2023 Dec;188(6):949-956.
http://doi.org/10.1007/s11046-023-00788-0
Epub 2023 Sep 15. PMID: 37713047.

Hector, R.F.; Sabouni, A. Methods and Compositions for Treating Fungal Infections in Animals. United States Patent USPN 5,789,387, 4 August 1998. [Google Scholar]

NikZ against Candida Auris

Poester, VR, Munhoz, LS; Benelli, JL; Melo, AM; Al-Hatmi, AMS; Larwood, DJ; Martinez, M; Stevens, D.; Xavier, MO, Initial Results of the International Efforts in Screening New Agents against Candida auris. J. Fungi 2022, 8, 771.
https://doi.org/10.3390/jof8080771 

Bentz ML, Nunnally N, Lockhart SR, Sexton DJ, Berkow EL. Antifungal activity of nikkomycin Z against Candida auris. J Antimicrob Chemother. 2021 May 12;76(6):1495-1497. doi: 10.1093/jac/dkab052. PMID: 33677578.

NikZ in other areas

Sass G, Kotta-Loizou I, Martinez M, Larwood DJ, Stevens DA. Polymycovirus Infection Sensitizes Aspergillus fumigatus for Antifungal Effects of Nikkomycin Z. Viruses. 2023 Jan 10;15(1):197.
http://doi.org/10.3390/v15010197
PMID: 36680240; PMCID: PMC9864188.

Poester VR, Munhoz LS, Stevens DA, Melo AM, Trápaga MR, Flores MM, Larwood DJ, Xavier MO. Nikkomycin Z for the treatment of experimental sporotrichosis caused by Sporothrix brasiliensis. Mycoses. 2023 Oct;66(10):898-905.
http://doi.org/10.1111/myc.13629
Epub 2023 Jul 11. PMID: 37434420.

Early Publications

Shubitz LF, Trinh HT, Perrill RH, Thompson CM, Hanan NJ, Galgiani JN, Nix DE. Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials. J Infect Dis. 2014 Jun 15;209(12):1949-54.
https://doi.org/10.1093/infdis/jiu029
Epub 2014 Jan 12. PMID: 24421256; PMCID: PMC4038145

Shubitz LF, Roy ME, Nix DE, Galgiani JN. Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. Med Mycol. 2013 Oct;51(7):747-54. doi: 10.3109/13693786.2013.770610.
Epub 2013 Mar 14. PMID: 23488972.